Mercurial > thoughts
diff org/ideas.org @ 141:94e03d638078
new ideas.
author | Robert McIntyre <rlm@mit.edu> |
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date | Thu, 26 Feb 2015 17:56:46 -0800 |
parents | 208424fee6f9 |
children | f40992b38f51 |
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1.1 --- a/org/ideas.org Thu Feb 05 23:05:45 2015 -0800 1.2 +++ b/org/ideas.org Thu Feb 26 17:56:46 2015 -0800 1.3 @@ -31,6 +31,50 @@ 1.4 getting credit. 1.5 #+end_quote 1.6 1.7 +- whole brain perfusion embedding :: Do the standard EM embedding 1.8 + protocol, but skip the osmium step, and use the "perfusion 1.9 + pausing" method to prevent overextraction during the dehydration 1.10 + and embedding steps. I think that you CAN perfuse resins into the 1.11 + brain, simply because you CAN perfuse viscous rubber when doing 1.12 + vascular casts. 1.13 + 1.14 +- perfusion pausing :: One problem with doing perfusion is that if you 1.15 + STOP the perfusion, you rapidly loose pressure in the organ as 1.16 + your perfusate leaks out. You can prevent this by submerging the 1.17 + organ/head/rat whatever in FLUID at the appropriate level. Use 1.18 + something inert like flurocarbon to avoid problems. You would 1.19 + have to slowly decrease the flow rate while simultaneously 1.20 + lowering the perfusing object into the fluid. To start again, 1.21 + reverse the process -- reengage the peristaltic pump slowly while 1.22 + removing the organ from the fluid. 1.23 + 1.24 +- evoultionary textbook mimiricy :: as surgery becomes more common, 1.25 + there develops a distinct selective pressure for individuals 1.26 + organ layout to look more like the medical textbooks! :P 1.27 + 1.28 +- transparent skin :: temporary / permament transparent skin. Allows 1.29 + for examination of organs / muscles and visual prevention of 1.30 + disease and detection or abnormalities / good things 1.31 + eg. excercise. 1.32 + 1.33 +- sweet information :: candy with a whole book written in it. Eat a 1.34 + book! 1.35 + 1.36 +- targeted immunosuppressant :: just kill off the B-cells and friends 1.37 + that would cause problems in a organ-transplant / other 1.38 + situation. AIDS is good at killing these cells -- maybe make it 1.39 + just target the ones that will cause problems. Then you can 1.40 + premptively kill off that part of someone's immune system before 1.41 + a transplant. ALSO, you can kill off everyone's defenses against 1.42 + other blood types and make people effectively type AB+ w.r.t 1.43 + blood transfusions. Actually, why not give babies this treatment 1.44 + so that they're automatically compatable with all blood types? 1.45 + The immune system has this already when it's first growing; maybe 1.46 + it can be "retrained" to accept new things, or the mechanism of 1.47 + immune cell death be co-opted for these purposes. 1.48 + 1.49 +- fuck you tetris :: tetris that actively gives you the worst possible piece. 1.50 + 1.51 - pockets :: more things should have them! 1.52 1.53 - colored shower head :: a shower head add on that measures the temp